eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| carcinoid syndrome | ||||
| Disease ID | 661 |
|---|---|
| Disease | carcinoid syndrome |
| Definition | A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed) |
| Synonym | carcinoid syndrome (disorder) carcinoid syndrome, malignant carcinoid syndromes, malignant carcinoids syndrome excessive serotonin secretion hormonal tumor hormonal tumor (disorder) hormonal tumour hormone secretion by carcinoid tumor hormone secretion by carcinoid tumors hormone secretion by carcinoid tumour malignant carcinoid syndrome malignant carcinoid syndrome [disease/finding] malignant carcinoid syndromes serotonin syndrome syndrome serotonin syndrome, malignant carcinoid syndromes, malignant carcinoid |
| Orphanet | |
| DOID | |
| ICD10 | |
| UMLS | C0024586 |
| MeSH | |
| SNOMED-CT | |
| Comorbidity | UMLS | Disease | Sentences' Count(Total Sentences:21) C0206754 | neuroendocrine tumor | 10 C0018799 | heart disease | 8 C0011991 | diarrhea | 8 C0206754 | neuroendocrine tumors | 7 C0011991 | diarrhoea | 2 C0206754 | neuroendocrine tumour | 2 C0494165 | liver metastases | 2 C0020538 | hypertension | 2 C0018824 | valvular heart disease | 2 C0027849 | neuroleptic malignant syndrome | 1 C0541912 | duodenal ca | 1 C0020428 | aldosteronism | 1 C0020598 | hypoglycaemia | 1 C1384514 | primary aldosteronism | 1 C0014117 | endocardial fibroelastosis | 1 C0149925 | small cell lung cancer | 1 C0494165 | hepatic metastases | 1 C0033975 | psychosis | 1 C0011570 | depression | 1 C0031117 | peripheral neuropathy | 1 C0242379 | lung cancer | 1 |
| Curated Gene | (Waiting for update.) |
| Inferring Gene | (Waiting for update.) |
| Text Mined Gene | (Waiting for update.) |
| Locus | (Waiting for update.) |
| Disease ID | 661 |
|---|---|
| Disease | carcinoid syndrome |
| Integrated Phenotype | (Waiting for update.) |
| Text Mined Phenotype | HPO | Name | Sentences' Count(Total Phenotypes:28) HP:0002014 | Diarrhea | 10 HP:0100570 | Carcinoid tumor | 10 HP:0002664 | Neoplasia | 8 HP:0010783 | Erythema | 5 HP:0001945 | Fever | 2 HP:0000822 | Hypertension | 2 HP:0002169 | Clonus | 1 HP:0001347 | Hyperreflexia | 1 HP:0009830 | Peripheral neuritis | 1 HP:0002045 | Abnormally low body temperature | 1 HP:0001289 | Confusion | 1 HP:0000717 | Autism | 1 HP:0002063 | Muscle rigidity | 1 HP:0100543 | Cognitive deficits | 1 HP:0002013 | Emesis | 1 HP:0012531 | Pain | 1 HP:0000716 | Depression | 1 HP:0001943 | Hypoglycemia | 1 HP:0001649 | Tachycardia | 1 HP:0000622 | Blurred vision | 1 HP:0000969 | Dropsy | 1 HP:0001706 | Endocardial fibroelastosis | 1 HP:0007430 | Generalized edema | 1 HP:0012532 | Chronic pain | 1 HP:0000709 | Psychosis | 1 HP:0030357 | Small cell lung carcinoma | 1 HP:0005208 | Secretory diarrhea | 1 HP:0001962 | Palpitations | 1 |
| Disease ID | 661 |
|---|---|
| Disease | carcinoid syndrome |
| Manually Symptom | UMLS | Name(Total Manually Symptoms:31) C2364050 | hypothermia C2039684 | systemic symptoms C2003861 | flushing C1963179 | nausea C1963123 | valvular heart disease C1963091 | diarrhea C1368041 | pancreatic somatostatinoma C1336705 | testicular carcinoid tumor C1027109 | scleroderma C0520679 | obstructive sleep apnoea C0494165 | liver metastases C0426576 | gastrointestinal symptoms C0267557 | secretory diarrhoea C0264545 | pleural fibrosis C0239182 | watery diarrhea C0235527 | right-sided heart failure C0234131 | motor dysfunction C0233401 | psychiatric symptoms C0221347 | acrocyanosis C0037285 | skin manifestations C0037284 | skin lesions C0034088 | pulmonary regurgitation C0034069 | lung fibrosis C0033975 | psychosis C0022660 | acute renal failure C0018801 | heart failure C0017086 | gangrene C0016978 | tumor of the gallbladder C0011991 | diarrhoea C0007121 | carcinoma of bronchus C0007095 | carcinoid tumor |
| Text Mined Symptom | UMLS | Name | Sentences' Count(Total Symptoms:8) C0011991 | diarrhea | 9 C0016382 | flushing | 5 C0007095 | carcinoid tumor | 4 C0494165 | liver metastases | 2 C0018824 | valvular heart disease | 2 C0011991 | diarrhoea | 2 C2039684 | systemic symptoms | 1 C0020672 | hypothermia | 1 |
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Text Mining Genotype(Total Genotypes:0) | |
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All Snps(Total Genotypes:0) | |
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GWASdb Annotation(Total Genotypes:0) | |
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GWASdb Snp Trait(Total Genotypes:0) | |
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Mapped by lexical matching(Total Items:0) |
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Mapped by homologous gene(Total Items:0) |
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| Disease ID | 661 |
|---|---|
| Disease | carcinoid syndrome |
| Case | (Waiting for update.) |